Home Antibody All anti-WNT10B antibodies
Also for WNT10B (NM_003394)
|Wnt10b antibody was raised against a 15 amino acid peptide from near the center of human Wnt10b.|
|Human, Mouse, Rat
||WB: 2 - 4 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens wingless-type MMTV integration site family, member 10B (WNT10B)|
Entrez Gene 7480 Human
Entrez Gene 22410 Mouse
Entrez Gene 315294 Rat
|Wnt10b is a member of the Wnt family, a gene family that encodes secreted signaling proteins that play crucial roles in normal development such as regulation of cell fate and patterning during embryogenesis as well as neoplastic transformation. Wnt10b is found in the mouse mammary tumor virus insertion site where it is activated and causes mammary tumors. Elevated levels of Wnt10b have also been detected in human breast carcinomas. Wnt10b is known to be involved in adipogenesis, maintaining the preadipocyte in an undifferentiated state. More recently, Wnt10b has been shown to promote epithelial cell differentiation and hair shaft growth, demonstrating that Wnt10b has multiple roles in cell growth and differentiation. Two isoforms of Wnt10b are known to exist; this antibody will only recognize the longer isoform. This Wnt10b antibody will not cross-react with Wnt10a.|
|Secreted ProteinDruggable Genome Wnt signaling pathwayHedgehog signaling pathwayMelanogenesisPathways in cancerBasal cell carcinoma|
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Western blot analysis of Wnt10b in human skeletal muscle tissue lysate with Wnt10b antibody at (A) 2 and (B) 4 ug/ml.
Immunohistochemistry of Wnt10b in human skeletal muscle with Wnt10b antibody at 2.5 ug/ml.