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Anti-WASL Antibody EPR6959
Also for WASL (NM_003941)
|A synthetic peptide corresponding to residues in human N-WASP was used as an immunogen.|
|Mouse, Human (Does not react with: Rat)
||Lot dependent; please refer to CoA along with shipment
|WB, ASSAY, IHC
||WB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100; ICC/IF: 1:50 - 1:100
|pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA|
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens Wiskott-Aldrich syndrome-like (WASL)|
Entrez Gene 8976 Human
Entrez Gene 73178 Mouse
|The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. N-WASP is a homolog of the WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. N-WASP has been shown to bind Cdc42 directly, and induce formation of long actin microspikes (1).|
|Druggable Genome Chemokine signaling pathwayAdherens junctionFc gamma R-mediated phagocytosisRegulation of actin cytoskeletonPathogenic Escherichia coli infection|
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Western blot - Anti-N WASP antibody [EPR6959]; All lanes : Anti-N WASP antibody [EPR6959] at 1/1000 dilution.Lane 1 : NIH 3T3 cell lysate.Lane 2 : F9 cell lysate.Lane 3 : L929 cell lysate.Lane 4 : HeLa cell lysate.Lane 5 : K562 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 55 kDa.
Other-Anti-N WASP antibody [EPR6959](TA311108); Equilibrium disassociation constant (KD)..
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-N WASP antibody [EPR6959]; TA311108, at 1/50, staining N WASP in formalin fixed, paraffin embedded Human papillary carcinoma tissue by Immunohistochemistry