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Anti-VTCN1 Antibody EP1165
Also for VTCN1 (NM_024626)
|A peptide corresponding to residues near N-term of human GNB2 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IP: 1:20; IHC-P: 1:250 - 1:500; ICC: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt.
|Homo sapiens V-set domain containing T cell activation inhibitor 1 (VTCN1), transcript variant 1|
|B7-H4; B7h.5; B7H4; B7S1; B7X; PRO1291; RP11-229A19.4; VCTN1|
|As a member of B7 family, B7-H4 (VTCN1) plays a critical role in the regulation of antigen-specific immune responses. B7-H4 is a co-stimulatory protein expressed in activated T cells and is involved in the negative regulation of cell-mediated immunity in peripheral tissues (1).B7-H4 ligation to its receptor BTLA T-lymphocytes results in inhibition of T-cell activation, cytokine secretion, and the development of cytotoxicity (2). B7-H4 protein is typically expressed on the surface of activated T-cells, B-cells, monocytes, and dendritic cells, but not in most normal tissues. In tissues, B7-H4 is over expressed in breast, endometrial, ovarian, renal cell (RCC), and non-small cell lung carcinomas (NSCLC). B7-H4 has been identified as an important cancer marker for breast and ovarian cancers.|
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Western blot - B7H4 antibody [EP1165]; All lanes : Anti-B7H4 antibody [EP1165] at 1/10000 dilution.Lane 1 : Human fetal spleen lysate.Lane 2 : Human fetal thymus lysate.Lane 3 : SKBR3 lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 31 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - B7H4 antibody [EP1165]; ab108336, at 1/250 dilution, staining B7H4 in paraffin-embedded Human tonsil tissue by Immunohistochemistry.