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Home Antibody All anti-VHL antibodies
UltraMAB

Anti-VHL GAT Antibody Polyclonal

Generated by Genomic Immunization

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA590023 Rabbit Polyclonal Von Hippel Lindau Antibody 100ug $325 In Stock
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WB(1)
IHC(7)
ELISA(1)

OriGene Data

ImmunogenDNA immunization. This antibody is specific for the N Terminus Region of the target protein.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman Concentration1.15mg/ml
Guaranteed Application *WB, ELISA, IHC Suggested Dilutions WB 1:20000, IHC 1:150, ELISA 1:100-1:2000
Buffer20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Purification The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
Note This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

Target NameHomo sapiens von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase (VHL), transcript variant 1
Alternative NameHRCA1; pVHL; RCA1; VHL1
Database LinkNP_000542
Entrez Gene 7428 Human
FunctionVon Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Related PathwayTranscription FactorsDruggable Genome Ubiquitin mediated proteolysisPathways in cancerRenal cell carcinoma

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY VHL (RC216151, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-VHL.
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ELISA: Von Hippel Lindau Antibody
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-VHL Rabbit Polyclonal antibody. (TA590023)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-VHL Rabbit Polyclonal antibody. (TA590023)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-VHL Rabbit Polyclonal antibody. (TA590023)
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Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-VHL Rabbit Polyclonal antibody. (TA590023)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-VHL Rabbit Polyclonal antibody. (TA590023)
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Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-VHL Rabbit Polyclonal antibody. (TA590023)
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Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-VHL Rabbit Polyclonal antibody. (TA590023)
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