Home Antibody All anti-VEGFA antibodies
Also for VEGFA (NM_001025370)
|A synthetic peptide made to an internal region of the human VEGFA protein sequence (between residues 150-250). [Swiss-Prot# P15692]|
|human, mouse, rat, porcine, hamster, horse, chicken, guinea porcine, dog, cow
||Lot dependent; please refer to CoA along with shipment
||WB: 1.0 ug/ml
|Tris-citrate/phosphate buffer, pH 7-8 and 0.1% sodium azide|
|Homo sapiens vascular endothelial growth factor A (VEGFA), transcript variant 6|
|MVCD1; VEGF; VPF|
|VEGFA is a member of the PDGF/VEGF growth factor family and is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. It has been shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis. |
Cytokine-cytokine receptor interaction
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Detection of VEGFA doublet in CSF-IR/VEGFA chimera transfected lysate. ECL 10 second exposure.