Vitamin D3 Receptor is the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. It belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism, though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in Vitamin D3 Receptor are associated with type II vitamin D-resistant rickets.
TGF Beta Signaling Pathway
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