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Anti-VAV1 PHOSPHO Antibody EP510Y


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA301013 Rabbit Monoclonal Antibody against VAV1 (Clone EP510Y) (Phospho-specific) 100ul $325 In Stock
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OriGene Data

ImmunogenA phosphor synthetic peptide corresponding to residues surrounding Tyrosine 174 of human Vav was used as an immnogen. This antibody detects Vav phosphorylated at Tyrosine 174.
Clone NameEP510Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:250000 - 1:500000; ICC: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens vav 1 guanine nucleotide exchange factor (VAV1), transcript variant 1
Alternative NameVAV
Database LinkNP_005419
Entrez Gene 7409 Human
FunctionThe Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav) (1). First discovered based on its transforming properties, Vav is expressed mainly in hematopoietic cells and a few non-hematopoietic tissues, such as the pancreas and tooth enamels (2). As a signaling transducer, Vav is involved in T-cell activated transduction of T-cell antigen receptor (TCR). T-cell stimulated and tyrosine phosphorylated Vav acts as a catalyst in the exchange of guanosine nucleotides on Rac-1, a GTP binding protein (3). Using a mouse model, Vav expression has been determined to play an essential role in the cyctosketetal, proliferative, and apoptotic pathways for developing lymphoid cells and its signal response (3).
Related PathwayTranscription FactorsDruggable Genome Chemokine signaling pathwayFocal adhesionNatural killer cell mediated cytotoxicityT cell receptor signaling pathwayB cell receptor signaling pathwayFc epsilon RI signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - VAV1 (phospho Y174) antibody [EP510Y]; All lanes : Anti-VAV1 (phospho Y174) antibody [EP510Y] at 1/500000 dilution.Lane 1 : Untreated Jurkat cell lysate.Lane 2 : Jurkat cell lysate treated with pervanadate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 101 kDa.Observed band size : 101 kDa.


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