 |
|
|
|
Home All anti-USP7 antibodies
Anti-USP7 Antibody EPR4253
TrueMAB™ Antibodies - Made against Authentic Protein Antigens
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for USP7 (NM_003470)
OriGene Data
| A synthetic peptide corresponding to residues in human USP7 was used as an immunogen. |
| EPR4253 |
Rabbit IgG |
| Human, Mouse, Rat |
|
| WB, IHC |
ICC: 1:100 - 250, IHC: 1:50 - 100, WB: 1:1,000-10,000, |
| Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| (Protein A or G Sepharose) |
Reference Data
| Homo sapiens ubiquitin specific peptidase 7 (herpes virus-associated) (USP7) |
| HAUSP; TEF1 |
| NP_003461 |
| USP7 (Ubiquitin-specific-processing protease 7) is a deubiquitinase that has been shown to regulate the p53-Mdm2 pathway (1). Cotransfection of p53 and USP7 stabilizes p53 through the removal of ubiquitin moieties from polyubiquitinated p53 (1). It also counteracts the destabilizing effect of Mdm2 by direct deubiquitination of p53 (2). Subsequently, USP7 has been shown to deubiquitinate Mdm2 and Mdmx, thereby stabilizing these proteins (2). USP7 interacts with herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 and Epstein-Barr virus EBNA1. EBNA1 shows a tenfold higher affinity than TP53 and can compete with it for USP7 binding (3). |
|
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
WB Image
Western blot analysis on (A) Ramos, (B) HeLa, (C) A431, (D) MCF-7, (E) C6, and (F) Raw264.7 cell lysates using anti-USP7 RabMAb .
IHC Image
Immunohistochemical staining of paraffin-embedded human colon tissue using anti-USP7 RabMAb .
Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:
- HRP
- Biotin
- PE
- FITC
- DyLight® 488
- DyLight® 550
- DyLight® 594
- DyLight® 633
* DyLight is a trademark of Thermo-Fisher Scientific
Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.
Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)
|
 |
