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Anti-USP22 Antibody EPR4352(2)


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal antibody against USP22
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC414666) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human USP22 was used as an immunogen.
Clone NameEPR4352(2) IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IF, FC Suggested DilutionsICC/IF: 1:200; WB: 1:1000 - 1:5000; IP: 1:10 - 1:100; FC: 1:10 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for ICC or IHC-P.

Reference Data

Target NameHomo sapiens ubiquitin specific peptidase 22 (USP22)
Alternative NameUSP3L
Database LinkNP_056091
Entrez Gene 23326 Human
FunctionUSP22 belongs to a large family of proteins with ubiquitin hydrolase activity (1). USP22 catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator (2). It is a death-from-cancer signature and a subunit of the hSAGA coactivator complex (3). It is recruited to specific promoters by activators such as MYC, where it is required for transcription. Moreover, USP22 is required for nuclear receptor-mediated transactivation and cell cycle progression (2).
Related PathwayProtease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - USP22 antibody [EPR4352(2)]; All lanes : Anti-USP22 antibody [EPR4352(2)] at 1/1000 dilution.Lane 1 : HeLa lysate.Lane 2 : Human placenta lysate.Lane 3 : HT-1376 lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 60 kDa.
Other-Anti-USP22 antibody [EPR4352(2)](TA310932); Equilibrium disassociation constant (KD)..
Immunocytochemistry/ Immunofluorescence - Anti-USP22 antibody [EPR4352(2)]; TA310932 (1/200) staining USP22 in HeLa cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.5% Triton X100 and counterstained with DAPI in order to highlight the nucleus (red).
Flow Cytometry - USP22 antibody [EPR4352(2)]; Flow cytometric analysis of permeabilized HeLa cells using 1/10 TA310932 (red) or a rabbit IgG (negative) (green).


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