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Home Antibody All anti-UNG antibodies

Anti-UNG Antibody Polyclonal

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA319734 Rabbit Polyclonal UNG2 Antibody 100ug $325 3-7 Days
LC418736 UNG HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)

OriGene Data

ImmunogenUNG2 antibody was raised against a 17 amino acid peptide near the amino terminus of human UNG2.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsELISA, WB: 1 - 2 ug/ml
Predicted MW Explanation Predicted: 34 kDa Observed: 33 kDa
BufferUNG2 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification UNG2 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens uracil-DNA glycosylase (UNG), transcript variant 1
Alternative NameDGU; HIGM4; HIGM5; UDG; UNG1; UNG15; UNG2
Database LinkNP_003353
Entrez Gene 7374 Human
Entrez Gene 22256 Mouse
FunctionUNG2 Antibody: The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promoters and alternative splicing. UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from DNA that arise through either misincorporation during replication or cytosine deamination. UNG2 can also be bound by the HIV-1 integrase and incorporated into the virion particle, suggesting that it is required to remove uracils from the viral genome. As the intrinsic antiviral protein APOBEC3G generates numerous uracils in the HIV genome during its replication, it may be that the UNG2 contributes to the APOBEC3G-mediated loss of infectivity by generating abasic sites in the viral genome.
Related PathwayStem cell - PluripotencyDruggable Genome Base excision repairPrimary immunodeficiency

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of UNG2 in 3T3 cell lysate with UNG2 antibody at 1 ug/mL in (A) the presence and (B) the absence of blocking peptide.
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