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Anti-UNC13D Antibody EPR4915
Also for UNC13D (NM_199242)
|A synthetic peptide corresponding to residues on the C-terminus in human Munc 13-4 was used as an immunogen.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:50 - 1:100; ICC: 1:50 - 1:100
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt.
|Homo sapiens unc-13 homolog D (C. elegans) (UNC13D)|
|FHL3; HLH3; HPLH3; Munc13-4|
|Munc 13-4, also known as protein unc-13 homolog D, is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis, and it is involved in the regulation of cytolytic granules secretion. Mutations in Munc 13-4 are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.|
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Western blot - Munc 13-4 antibody [EPR4915]; All lanes : Anti-Munc 13-4 antibody [EPR4915] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : HuT-78 cell lysate.Lane 3 : JAR cell lysate.Lane 4 : Human placenta tissue lysate.Lane 5 : Human tonsil tissue lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 123 kDa.Observed band size : 110 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Munc 13-4 antibody [EPR4915]; TA307785, at 1/50 dilution, staining Munc 13-4 in Human tonsil tissue by immunohistochemistry.