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Anti-UNC13D Antibody EPR4915
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Also for UNC13D (NM_199242)
|A synthetic peptide corresponding to residues on the C-terminus in human Munc 13-4 was used as an immunogen.|
||ICC: 1:50 - 100, IHC: 1:50 - 100, IP: 1:10 - 100, WB: 1:1,000 - 10,000,
|Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens unc-13 homolog D (C. elegans) (UNC13D)|
|FHL3; HLH3; HPLH3; Munc13-4|
|Munc 13-4, also known as protein unc-13 homolog D, is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis, and it is involved in the regulation of cytolytic granules secretion. Mutations in Munc 13-4 are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.|
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Western blot analysis on (A) Jurkat, (B) HuT-78, (C) JAR, (D) human placenta, and (E) human tonsil lysates using anti-Munc 13-4 RabMAb .
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Munc 13-4 RabMAb .