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TP63 UltraMAB Antibody, Clone UMAB4
UltraMAB Antibodies - Validated with 10K Protein Chip
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Also for TP63 (NM_003722)
|Full length human recombinant protein of human TP63 (NP_003713) produced in HEK293T cell.|
|Human , Dog , Monkey
||0.5~1.0 mg/ml (Lot Dependent)
||WB 1:1000~2000; IHC 1:150
|PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography
|Homo sapiens tumor protein p63 (TP63), transcript variant 1|
|AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4|
|This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.|
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Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-TP63 monoclonal antibody (Clone UMAB4).
Immunohistochemical staining of paraffin-embedded Carcinoma of lung tissue using anti-TP63 mouse monoclonal antibody (Clone UMAB4; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min).
Immunohistochemical staining of paraffin-embedded prostate tissue using anti-TP63 mouse monoclonal antibody (Clone UMAB4; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min).