RAP80 is an ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. It plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1/BARD1 complex to sites of DNA damage at double-strand breaks (1). RAP80 contains an ubiquitin-interaction motif (UIM) that is associated with the complex through its interaction with CCDC98. Furthermore, it is reported to interact with the estrogen receptor a (ERa) in an agonist-dependent manner and is able to regulate ERa transcriptional activity (2).
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