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Anti-UCHL3 Antibody EP5331
Also for UCHL3 (NM_001270952)
|A synthetic peptide corresponding to residues at the N-terminus of human UCHL3 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
|Homo sapiens ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) (UCHL3), transcript variant 1|
Entrez Gene 7347 Human
Entrez Gene 50933 Mouse
Entrez Gene 498560 Rat
|UCHL3 is a deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. It is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. UCHL3 has a 10-fold preference for Arg and Lys at position P3". It deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. UCHL3 indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. It is required for stress-response retinal, skeletal muscle and germ cell maintenance. UCHL3 may be involved in working memory. |
|ProteaseDruggable Genome |
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Western blot - Anti-UCHL3 antibody [EP5331]; All lanes : Anti-UCHL3 antibody [EP5331] at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : 293T cell lysate.Lane 3 : SH-SY5Y cell lysate.Lane 4 : Jurkat cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Standard HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 26 kDa.Observed band size : 26 kDa.
Other-Anti-UCHL3 antibody [EP5331](TA310917); Equilibrium disassociation constant (KD)..