Home All anti-UCHL3 antibodies
Anti-UCHL3 Antibody EP5331
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for UCHL3 (NM_001270952)
|A synthetic peptide corresponding to residues at the N-terminus of human UCHL3 was used as an immunogen.|
|Human, Mouse, Rat
||WB: 1:1,000 - 10,000; IHC 1:50 - 100; ICC: 1:100 - 250; FC: 1:100 - 500;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) (UCHL3), transcript variant 1|
|UCHL3 is a deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. It is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. UCHL3 has a 10-fold preference for Arg and Lys at position P3". It deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. UCHL3 indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. It is required for stress-response retinal, skeletal muscle and germ cell maintenance. UCHL3 may be involved in working memory. |
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Western blot analysis on (A) K562, (B) 293T, (C) SH-SY5Y, and (D) Jurkat cell lysates using anti-UCHL3 RabMAb