Anti-UCHL3 Antibody, EP5331

Also for UCHL3 (NM_001270952)

OriGene Data

Immunogen	A synthetic peptide corresponding to residues at the N-terminus of human UCHL3 was used as an immunogen.
Clone Name	EP5331	Isotype
Species Reactivity	Human, Mouse, Rat	Concentration
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:1,000 - 10,000; IHC 1:50 - 100; ICC: 1:100 - 250; FC: 1:100 - 500;
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) (UCHL3), transcript variant 1
Alternative Name	UCH-L3
Database Link	NP_001257881
Function	UCHL3 is a deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. It is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. UCHL3 has a 10-fold preference for Arg and Lys at position P3". It deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. UCHL3 indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. It is required for stress-response retinal, skeletal muscle and germ cell maintenance. UCHL3 may be involved in working memory.
Related Pathway

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WB Image

Western blot analysis on (A) K562, (B) 293T, (C) SH-SY5Y, and (D) Jurkat cell lysates using anti-UCHL3 RabMAb

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OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

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Anti-UCHL3 Antibody EP5331

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data