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Anti-UBE2N Antibody EPR5162
Also for UBE2N (NM_003348)
|A synthetic peptide corresponding to residues in human UBC-13 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC/IF: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens ubiquitin-conjugating enzyme E2N (UBE2N)|
|HEL-S-71; UBC13; UbcH-ben; UbcH13; UBCHBEN|
Entrez Gene 7334 Human
Entrez Gene 93765 Mouse
Entrez Gene 116725 Rat
|UBC-13 is a ubiquitin-conjugating enzyme which plays a role in the control of progress through the cell cycle and differentiation. It also plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. UBC-13 acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair (1). In addition, UBC-13 is responsible for noncanonical ubiquitination of TNF receptor-associated factor (TRAF)-family adapter proteins involved in Toll-like receptor and TNF-family cytokine receptor signaling, which are regulators of innate immunity (2).|
|Druggable Genome Ubiquitin mediated proteolysis|
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Western blot - Ube2N / Ubc13 antibody [EPR5162]; All lanes : Anti-Ube2N / Ubc13 antibody [EPR5162] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : Daudi cell lysate.Lane 3 : Human heart lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 17 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Ube2N / Ubc13 antibody [EPR5162]; Immunohistochemical analysis of paraffin-embedded Human testis tissue using TA307861 at 1/100 dilution.