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Home Antibody All anti-UBE2N antibodies

Anti-UBE2N Antibody EPR5162

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307861
  • Rabbit monoclonal antibody against UBC-13(clone EPR5162)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418741) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for UBE2N (NM_003348)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human UBC-13 was used as an immunogen.
Clone NameEPR5162 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC/IF: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens ubiquitin-conjugating enzyme E2N (UBE2N)
Alternative NameHEL-S-71; UBC13; UbcH-ben; UbcH13; UBCHBEN
Database LinkNP_003339
Entrez Gene 7334 Human
Entrez Gene 93765 Mouse
Entrez Gene 116725 Rat
FunctionUBC-13 is a ubiquitin-conjugating enzyme which plays a role in the control of progress through the cell cycle and differentiation. It also plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. UBC-13 acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair (1). In addition, UBC-13 is responsible for noncanonical ubiquitination of TNF receptor-associated factor (TRAF)-family adapter proteins involved in Toll-like receptor and TNF-family cytokine receptor signaling, which are regulators of innate immunity (2).
Related PathwayDruggable Genome Ubiquitin mediated proteolysis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Ube2N / Ubc13 antibody [EPR5162]; All lanes : Anti-Ube2N / Ubc13 antibody [EPR5162] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : Daudi cell lysate.Lane 3 : Human heart lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 17 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Ube2N / Ubc13 antibody [EPR5162]; Immunohistochemical analysis of paraffin-embedded Human testis tissue using TA307861 at 1/100 dilution.

 

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