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Home Antibody All anti-Tyrobp antibodies

Anti-Tyrobp Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319099
  • Rabbit polyclonal anti-TYROBP (DAP12) antibody
100ug 325 3-7 Days
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WB(1)
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Also for Tyrobp (NM_198125)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenSynthetic peptide corresponding to residues surrounding amino acids 94 of mouse DAP-12
Clone Name IsotypeRabbit IgG
Species ReactivityMouse, rat Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 0.5-4 ug/ml
Buffer100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Purification Affinity purified

Reference Data

Target NameHomo sapiens TYRO protein tyrosine kinase binding protein (TYROBP), transcript variant 2
Alternative NameDAP12; KARAP; PLOSL
Database LinkNP_937758
Entrez Gene 22177 Mouse
Entrez Gene 361537 Rat
FunctionDAP12 (KARAP) is a natural killer (NK) cell-expressed cell surface receptor and belongs to the immunoglobulin and C-type lectin superfamily. Unlike other members of this family which possess immunoreceptor tyrosine-based inhibitory motifs (ITIM), DAP12 contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and is present as a disulphide-bonded homodimer. Crosslinking of DAP 12-KIR complexes (membrane glycoproteins of the killer-cell inhibitory receptor family without an ITIM in their cytoplasmic domain) results in cellular activation.
Related PathwayTransmembraneDruggable Genome Natural killer cell mediated cytotoxicity

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of DAP12 expression in rat kidney tissue lysate.

 

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