Home Antibody All anti-Tlr7 antibodies
Also for Tlr7 (NM_016562)
|TLR7 antibody was raised against a peptide corresponding to 14 amino acids near the middle of mouse TLR7.|
||ELISA, WB: 0.5 - 2 ug/ml, ICC: 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Ion exchange chromatography purified
|Homo sapiens toll-like receptor 7 (TLR7)|
Entrez Gene 51284 Human
Entrez Gene 170743 Mouse
|Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (4,5). TLR7, like TLRs 3, 8, and 9, is localized in intracellular acidic compartments such as the phagolysosome (6) and will recognize some single-stranded RNA viruses such as vesicular stomatitis virus (VSV) and influenza virus (7). Activation of TLR7 by VSV results in stimulation of the immune response including IFNΑ secretion, suggesting the importance of TLR7 in virus recognition.|
Toll-like receptor signaling pathway
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Western blot analysis of TLR7 in Daudi cell lysates with TLR7 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.
Immunocytochemistry staining of Daudi cells using TLR7 antibody at 2 ug/mL.