Home Antibody All anti-Tlr4 antibodies
Also for Tlr4 (NM_003266)
|Synthetic peptide corresponding to residues surrounding amino acids 819 of rat TLR4|
|Human, mouse, rat
|100 µg (0.5 mg/ml) affinity purified rabbit anti-TLR4 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Homo sapiens toll-like receptor 4 (TLR4), transcript variant 3|
|ARMD10; CD284; TLR-4; TOLL|
|TLR4 (Toll-like receptor 4) is a mammalain homologue of the Drosophila toll protein. The human TLR4 is a type-1 transmembrane protein containing 799 amino acid residues. The extracellular domain has leucine-rich repeats and the intracellular domain is similar to that of IL-1 receptor. TLR4 is a receptor for lipopolysaccharide (LPS). In mice that are genetically tolerant to endotoxin, mutations have been identified in the intracellular domain of TLR4 that abolish LPS responsiveness. TLR4 uses a mechanism similar to that of the IL-1 receptor for signal transduction that leads to activation of NF-kB.|
Toll-like receptor signaling pathway
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Western blot analysis of TLR4 in rat kidney tissue lysate.