Home Antibody All anti-TYMS antibodies
Also for TYMS (NM_001071)
|Recombinant fragment corresponding to a region within amino acids 122 and 313 of Thymidylate synthetase (Uniprot ID#P04818)|
|Human (Predicted: Mouse, Monkey, Pig, Rat, Zebrafish, Xenopus tropicalis)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Mouse (94%), Monkey (98%), Pig (96%), Rat (95%), Zebrafish (87%), Xenopus tropicalis (85%)
|Homo sapiens thymidylate synthetase (TYMS)|
|HST422; TMS; TS|
Entrez Gene 7298 Human
Entrez Gene 22171 Mouse
Entrez Gene 29261 Rat
Entrez Gene 697580 Monkey
|Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq]|
|Druggable Genome Pyrimidine metabolismOne carbon pool by folateMetabolic pathways|
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Sample (30 ug of whole cell lysate). A: H1299. 10% SDS PAGE. TA308802 diluted at 1:1000.