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Home Antibody All anti-TYMS antibodies

Anti-TYMS Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308802
  • Rabbit polyclonal antibody to Thymidylate synthetase (thymidylate synthetase)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC420700) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for TYMS (NM_001071)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 122 and 313 of Thymidylate synthetase (Uniprot ID#P04818)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Mouse, Monkey, Pig, Rat, Zebrafish, Xenopus tropicalis) Concentration1mg/ml
Guaranteed Application *WB Suggested DilutionsWB:1:500-1:3000
Predicted MW Explanation 36kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Mouse (94%), Monkey (98%), Pig (96%), Rat (95%), Zebrafish (87%), Xenopus tropicalis (85%)

Reference Data

Target NameHomo sapiens thymidylate synthetase (TYMS)
Alternative NameHST422; TMS; TS
Database LinkNP_001062
Entrez Gene 7298 Human
Entrez Gene 22171 Mouse
Entrez Gene 29261 Rat
Entrez Gene 697580 Monkey
FunctionThymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq]
Related PathwayDruggable Genome Pyrimidine metabolismOne carbon pool by folateMetabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample (30 ug of whole cell lysate). A: H1299. 10% SDS PAGE. TA308802 diluted at 1:1000.

 

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