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Anti-TSC1 Antibody EP318Y
Also for TSC1 (NM_000368)
|A synthetic peptide corresponding to C-terminal residues of human TSC1/Hamartin was used as an immunogen.|
||Lot dependent; please refer to CoA along with shipment
||WB: 1:20000; IHC-P: Use at an assay dependent dilution
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Homo sapiens tuberous sclerosis 1 (TSC1), transcript variant 1|
Entrez Gene 7248 Human
|Tuberous sclerosis complexes-1 (TCS1 also known as Hamartin) is a tumor suppressor that form a complex with TSC2 (Tuberin. This complex is known to control various cellular functions including cell cycle, endocytosis, adhesion, and transcription (1). The TSC1/TSC2 complex inhibits phosphorylation of S6kinase and 4E-BP1 through inactivation of mTOR (2). Recently it has been shown that TSC1/Hamartin is localized to the centrosome and negatively regulates Plk1 implicating TSC1/hamartin to the regulation of centrosome duplication (3). Tuberous sclerosis (TSC), an autosomal dominant disorder that affects 1 in 6000 individuals, is caused by a mutation in either the TSC1 or TSC2 tumor suppressor gene. |
| mTOR signaling pathwayInsulin signaling pathway|
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Western blot - Hamartin antibody [EP318Y]; Anti-Hamartin antibody [EP318Y] at 1/20000 dilution + HeLa cell lysate.Predicted band size : 150 kDa.Observed band size : 150 kDa.
Immunohistochemistry (Paraffin-embedded sections) - Hamartin antibody [EP318Y]; Ab40872 staining human Hamartin in human kidneys by immunohistochemistry using paraffin embedded tissue.