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Home Antibody All anti-TRIP10 antibodies

Anti-TRIP10 Antibody EPR1965

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307313
  • Rabbit monoclonal antibody against CIP4(clone EPR1965)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418125) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for TRIP10 (NM_004240)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human CIP4 was used as an immunogen.
Clone NameEPR1965 IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens thyroid hormone receptor interactor 10 (TRIP10), transcript variant 2
Alternative NameCIP4; HSTP; STOT; STP; TRIP-10
Database LinkNP_004231
FunctionCIP4 (Cdc42-interacting protein 4) is a Cdc42 effector that is required for the translocation of GLUT4 to the plasma membrane in response to insulin signaling. It is involved in coordinating membrane tabulation, with reorganization of the actin cytoskeleton during endocytosis. CIP4 binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine, promoting membrane invagination and the formation of tubules. It promotes Cdc42-induced actin polymerization by recruiting WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. CIP4 is also required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. Furthermore, CIP4 interacts with GTP-bound RHOQ. It is expressed in the brain, colon, heart, kidney, and other tissues (1).
Related Pathway

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WB Image
Western blot - Cip4 antibody [EPR1965]; All lanes : Anti-Cip4 antibody [EPR1965] at 1/1000 dilution.Lane 1 : JAR cell lysate.Lane 2 : HepG2 cell lysate.Lane 3 : TF1 cell lysate.Lane 4 : HeLa cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 68 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cip4 antibody [EPR1965]; TA307313 at 1/100 dilution staining Cip4 in paraffin embedded Human stomach tissue.

 

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