Home Antibody All anti-TRIM71 antibodies
Anti-TRIM71 Antibody Polyclonal
Also for TRIM71 (NM_001039111)
|TRIM71 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TRIM71.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|TRIM71 Antibody is supplied in PBS containing 0.02% sodium azide.|
|TRIM71 Antibody is affinity chromatography purified via peptide column. (Protein A or G Sepharose)
|Homo sapiens tripartite motif containing 71, E3 ubiquitin protein ligase (TRIM71)|
|TRIM71 Antibody: TRIM71 is the mammalian ortholog to the C. elegans heterochronic protein Lin41, a protein that is thought to be important in postembryonic development, and is genetically and biochemically downstream of both Shh and Fgf signaling pathways. Similar to its C. elegans homolog, TRIM71 is a target of the microRNA let-7 and is likely to play a role in mammalian development. Recent experiments have indicated that TRIM71 is an E3 ubiquitin ligase and can interact with the Dicer and the Argonaute proteins Ago1, Ago2, and Ago4. Overexpression and depletion of TRIM71 led to inverse changes in Ago2 protein levels, suggesting TRIM71 can regulate Ago2 turnover. Finally, TRIM71 cooperates with the pluripotency factor Lin-28 in regulating let-7.|
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Western blot analysis of TRIM71 in human brain tissue lysate with TRIM71 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of TRIM71 in human brain tissue with TRIM71 antibody at 5 ug/mL.