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Anti-TPO Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA309510 Goat Polyclonal Antibody against thyroid peroxidase 100ug $325 3-7 Days
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OriGene Data

ImmunogenPeptide with sequence C-TRHVIQVSNEVVTDD, from the internal region of the protein sequence according to NP_000538.3; NP_783650.1; NP_783652.1; NP_783653.1.
Clone Name Isotype
Species ReactivityTest: Human. Expected from seq similarity: Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB 0.3-1ug/ml; IHC 5-10ug/ml
BufferSupplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Note IHC: In paraffin embedded Human Thyroid Gland shows textured staining in the cytoplasm of epithelial cells.

Reference Data

Target NameHomo sapiens thyroid peroxidase (TPO), transcript variant 2
Alternative NameMSA; TDH2A; TPX
Database LinkNP_783650
Entrez Gene 7173 Human
FunctionThis gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq].
Related PathwayES Cell Differentiation/IPSTransmembraneDruggable Genome Tyrosine metabolismMetabolic pathwaysCytokine-cytokine receptor interactionJak-STAT signaling pathwayHematopoietic cell lineageAutoimmune thyroid diseaseMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
A309510 (0.3µg/ml) staining of Human Thyroid Gland lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

IHC Image
TA309510 (5ug/ml) staining of paraffin embedded Human Thyroid Gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.


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