Home Antibody All anti-TP53I3 antibodies
Also for TP53I3 (NM_004881)
|Recombinant fragment corresponding to a region within amino acids 1 and 332 of PIG3 (Uniprot ID#Q53FA7)|
|Human (Predicted: Bovine)
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Bovine (88%)
|Homo sapiens tumor protein p53 inducible protein 3 (TP53I3), transcript variant 1|
Entrez Gene 9540 Human
|The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]|
|Druggable Genome p53 signaling pathway|
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Sample (30 ug of whole cell lysate). A: Hep G2 . 10% SDS PAGE. TA308561 diluted at 1:1000.
Immunohistochemical analysis of paraffin-embedded H441 xenograft, using PIG3(TA308561) antibody at 1:500 dilution.
Immunofluorescence analysis of paraformaldehyde-fixed A549, using PIG3 (TA308561) antibody at 1:200 dilution.