UltraMAB™ Antibodies - Validated with 10K Protein Chip
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-TP53 mouse monoclonal antibody. (UM500053)
Immunohistochemical staining of paraffin-embedded Human normal colon tissue and colorectal cancer tissue using anti-TP53 mouse monoclonal antibody. (UM500053)
Immunohistochemical staining of paraffin-embedded Human normal endometrium tissue and endometrium adenocarcinoma tissue using anti-TP53 mouse monoclonal antibody. (UM500053)
OriGene overexpression protein microarray chip was immunostained with UltraMAB anti-TP53 mouse monoclonal antibody (UM500053). The positive reactive proteins are highlighted with two red arrows in the enlarged subarray. All the positive controls spotted in this subarray are also labeled for clarification.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [provided by RefSeq, Jul 2008].
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Immunohistochemical staining of paraffin-embedded Human normal colon tissue and colorectal cancer tissue using anti-TP53 mouse monoclonal antibody. (UM500053)
Immunohistochemical staining of paraffin-embedded Human normal endometrium tissue and endometrium adenocarcinoma tissue using anti-TP53 mouse monoclonal antibody. (UM500053)
OriGene overexpression protein microarray chip was immunostained with UltraMAB anti-TP53 mouse monoclonal antibody (UM500053). The positive reactive proteins are highlighted with two red arrows in the enlarged subarray. All the positive controls spotted in this subarray are also labeled for clarification.
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