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Home Antibody All anti-TP53 antibodies

Anti-TP53 Antibody EPR354(3)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307692
  • Rabbit monoclonal antibody against p53 Acetyl (K305)(clone EPR354(3))
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400186) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for TP53 (NM_000546)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic acetylated peptide corresponding to residues surrounding Lysine 305 of human p53 was used as an immunogen. The antibody only detects p53 acetylated on Lysine 305.
Clone NameEPR354(3) IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens tumor protein p53 (TP53), transcript variant 1
Alternative NameBCC7; LFS1; P53; TRP53
Database LinkNP_000537
Functionp53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair (1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers (3). p53 is frequently mutated or inactivated in about 60% of cancers. It is acetylated at lysine 305, which is a p300 acetyltransferase-mediated acetylation site (4).
Related Pathway
Apoptosis
Cell cycle
Delta-Notch Signaling Pathway
MAPK signaling pathway
Senescence and Autophagy
TGF Beta Signaling Pathway
Wnt Signaling Pathway

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WB Image
Western blot - p53 (acetyl K305) antibody [EPR354(3)]; All lanes : Anti-p53 (acetyl K305) antibody [EPR354(3)] at 1/1000 dilution.Lane 1 : HepG2 cell lysate, untreated.Lane 2 : HepG2 cell lysate, treated with etoposide and TSA.Lysates/proteins at 10 µg per lane.Predicted band size : 44 kDa.

 

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