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Anti-TP53 Antibody EPR354(3)
Also for TP53 (NM_000546)
|A synthetic acetylated peptide corresponding to residues surrounding Lysine 305 of human p53 was used as an immunogen. The antibody only detects p53 acetylated on Lysine 305.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens tumor protein p53 (TP53), transcript variant 1|
|BCC7; LFS1; P53; TRP53|
Entrez Gene 7157 Human
Entrez Gene 24842 Rat
|p53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair (1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers (3). p53 is frequently mutated or inactivated in about 60% of cancers. It is acetylated at lysine 305, which is a p300 acetyltransferase-mediated acetylation site (4).|
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Western blot - p53 (acetyl K305) antibody [EPR354(3)]; All lanes : Anti-p53 (acetyl K305) antibody [EPR354(3)] at 1/1000 dilution.Lane 1 : HepG2 cell lysate, untreated.Lane 2 : HepG2 cell lysate, treated with etoposide and TSA.Lysates/proteins at 10 ug per lane.Predicted band size : 44 kDa.