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Home All anti-TP53 antibodies
Anti-TP53 Antibody E26
TrueMAB™ Antibodies - Made against Authentic Protein Antigens
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for TP53 (NM_000546)
OriGene Data
| A synthetic peptide corresponding to residues following the transcription activation domain of human p53 was used as immunogen. The antibody should recognize human wild-type and mutant p53. |
| E26 |
IgG |
| Human |
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| WB, IHC, IF |
WB: 1: 1,000; IHC: 1: 100; ICC: 1:50100 |
| 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
| (Protein A or G Sepharose) |
Reference Data
| Homo sapiens tumor protein p53 (TP53), transcript variant 1 |
| BCC7; LFS1; P53; TRP53 |
| NP_000537 |
| p53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair(1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers(3). p53 is frequently mutated or inactivated in about 60% of cancers (4,5). |
Apoptosis Cell cycle Delta-Notch Signaling Pathway MAPK signaling pathway Senescence and Autophagy TGF Beta Signaling Pathway Wnt Signaling Pathway |
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
WB Image
Western blot analysis of Jurkat cell lysate using anti-p53, 1:1,000 dilution.
IHC Image
Immunohistochemical analysis of paraffin embedded human breast carcinoma showing nuclear localization of p53 using anti p53
IF Image
Immunofluorescent staining of A431 cells using anti p53
Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:
- HRP
- Biotin
- PE
- FITC
- DyLight® 488
- DyLight® 550
- DyLight® 594
- DyLight® 633
* DyLight is a trademark of Thermo-Fisher Scientific
Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.
Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)
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