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Anti-TP53 Antibody E26
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Also for TP53 (NM_000546)
|A synthetic peptide corresponding to residues following the transcription activation domain of human p53 was used as immunogen. The antibody should recognize human wild-type and mutant p53.|
|WB, IHC, IF
||WB: 1: 1,000; IHC: 1: 100; ICC: 1:50100
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens tumor protein p53 (TP53), transcript variant 1|
|BCC7; LFS1; P53; TRP53|
|p53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair(1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers(3). p53 is frequently mutated or inactivated in about 60% of cancers (4,5).|
Delta-Notch Signaling Pathway
MAPK signaling pathway
Senescence and Autophagy
TGF Beta Signaling Pathway
Wnt Signaling Pathway
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Western blot analysis of Jurkat cell lysate using anti-p53, 1:1,000 dilution.
Immunohistochemical analysis of paraffin embedded human breast carcinoma showing nuclear localization of p53 using anti p53
Immunofluorescent staining of A431 cells using anti p53