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Home Antibody All anti-TP53 antibodies

Anti-TP53 Antibody E26

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300340
  • Rabbit Monoclonal Antibody against TP53 (Clone E26)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400186) , 20ug
100ul $325 In Stock
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WB(1)
IHC(2)
IF(1)
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Also for TP53 (NM_000546)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues following the transcription activation domain of human p53 was used as immunogen. The antibody should recognize human wild-type and mutant p53.
Clone NameE26 IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1: 1,000; IHC: 1: 100; ICC: 1:50100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens tumor protein p53 (TP53), transcript variant 1
Alternative NameBCC7; LFS1; P53; TRP53
Database LinkNP_000537
Functionp53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair(1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers(3). p53 is frequently mutated or inactivated in about 60% of cancers (4,5).
Related Pathway
Apoptosis
Cell cycle
Delta-Notch Signaling Pathway
MAPK signaling pathway
Senescence and Autophagy
TGF Beta Signaling Pathway
Wnt Signaling Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - p53 antibody [E26]; Anti-p53 antibody [E26] at 1/1000 dilution + Jurkat cell lysate.Predicted band size : 44 kDa.Observed band size : 53 kDa .
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - p53 antibody [E26]; Immunohistochemical analysis of paraffin embedded human breast carcinoma showing nuclear localization of p53 using TA300340 at 1/100 dilution.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p53 antibody [E26]; Immunohistochemical analysis of Human urinary bladder cancer tissue, staining p53 with TA300340 at 1/250 dilution. Staining was detected using DAB.
IF Image
Immunocytochemistry/ Immunofluorescence - p53 antibody [E26]; Immunofluorescent staining of A431 cells using TA300340 at 1/100 dilution.

 

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