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Home Antibody All anti-TOMM70A antibodies

Anti-TOMM70A Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306693
  • Rabbit Polyclonal TOM70 Antibody
100ug $325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenTOM70 antibody was raised against a 17 amino acid peptide near the amino terminus of human TOM70.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 2 - 4 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) (TOMM70A)
Alternative NameFLJ90470
Database LinkNP_055635
FunctionThe translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria. TOM70, an important member of the TOM complex, contains a tetratricopeptide repeat domain similar to those found in cytosolic chaperones such as Hsp90 and Hsc70 and provides a docking site for these proteins. This interaction is thought to be a critical first step in the TOM70-dependent mitochondrial import, followed by contact between the preprotein and TOM70. After targeting to TOM70, preproteins are translocated through the outer membrane via the TOM40 import pore complex. The precise mechanism of how preproteins progress from TOM70 to TOM40 to full translocation is still unclear. At least two isoforms of TOM70 are known to exist.
Related Pathway

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WB Image
Western blot analysis of TOM70 in 293 cell lysate with TOM70 antibody at 2 ug/ml.
IHC Image
Immunohistochemistry of TOM70 in mouse brain tissue with TOM70 antibody at 2.5 ug/ml.

 

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