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Home Antibody All anti-TNFSF4 antibodies

Anti-TNFSF4 Antibody EP1168Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307366
  • Rabbit monoclonal antibody against OX40L (clone EP1168Y )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401143) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for TNFSF4 (NM_003326)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus of human OX40L was used as an immunogen.
Clone NameEP1168Y IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:10000 - 1:50000
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens tumor necrosis factor (ligand) superfamily, member 4 (TNFSF4), transcript variant 1
Alternative NameCD134L; CD252; GP34; OX-40L; OX4OL; TXGP1
Database LinkNP_003317
Entrez Gene 7292 Human
FunctionTumor necrosis factor receptor superfamily member 4 (OX40, CD134) is a membrane receptor found on activated CD4+ and CD8+ T cells and B cells (1). OX40 binds to OX40 ligand (OX40L) and other TNF receptor-associated factors (TNAF2, TRAF3, TRAF5). OX40-OX40L complex produces CD28 independent co-stimulatory signals. OX40 is involved in the pathologic cytokine storm associated in certain viral infection, such as H4N1 bird flu. OX40 starts a survival signal to the T-cell preventing activation-induced apoptosis, but up regulates cytokine production. Inhibition of OX40 using OX40-immunoglobulin has been linked to reduction of immune overreaction without affecting the viral clearance (2).
Related PathwayTransmembraneDruggable Genome Cytokine-cytokine receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - CD134 / OX40 antibody [EP1168Y]; All lanes : Anti-CD134 / OX40 antibody [EP1168Y] at 1/50000 dilution.Lane 1 : recombinant CD134 / OX40 at 0.01 ug.Lane 2 : recombinant CD134 / OX40 at 0.005 ug.Secondary.goat anti-rabbit-HRP at 1/1000 dilution.Predicted band size : 30 kDa.Observed band size : 50 kDa .

 

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