Read Promotion Error: could not connect to redis Instance at 127.0.0.1:6912 Anti-TNFSF10 Antibody, RIK-2 - OriGene
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Anti-TNFSF10 Antibody RIK-2

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA320501 Mouse Anti-Human CD253 (TRAIL) Purified (25 ug) 25ug 3-7 Days
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FC(1)
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Also for TNFSF10 (NM_003810)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

Immunogen
Clone NameRIK-2 Isotype
Species ReactivityHuman Concentration0.5-1mg/ml (lot dependent)
Guaranteed Application *FC Suggested DilutionsFlow, Functional Assay
BufferAqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Purification Affinity purified

Reference Data

Target NameHomo sapiens tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10), transcript variant 1
Alternative NameApo-2L; APO2L; CD253; TL2; TRAIL
Database LinkNP_003801
Entrez Gene 8743 Human
FunctionThe RIK-2 monoclonal antibody reacts with human TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily. TRAIL is not expressed by resting human cells but has been shown to be induced under certain activation conditions. Iin addition it is expressed on several human tumor lines. Interaction of TRAIL with its ligand, Apo-2, induces apoptosis. RIK-2 blocks TRAIL-induced apoptosis.
Related PathwayTransmembraneDruggable Genome Cytokine-cytokine receptor interactionApoptosisNatural killer cell mediated cytotoxicity

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Surface staining of human Trail transfected cells with Anti-Human CD253 (TRAIL) PE. Appropriate isotype controls were used (open histogram). Total viable cells were used for analysis.
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