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Home Antibody All anti-TNFRSF1A antibodies

Anti-TNFRSF1A Antibody EP1651AY

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301202
  • Rabbit Monoclonal Antibody against TNFRSF1A (Clone EP1651AY)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400435) , 20ug
100ul 325 In Stock
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WB(1)
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Also for TNFRSF1A (NM_001065)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to the extracellular portion of human TNFR1 was used as immunogen.
Clone NameEP1651AY IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:500; FC: 1:30
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A)
Alternative NameCD120a; FPF; MS5; p55; p55-R; p60; TBP1; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
Database LinkNP_001056
FunctionTumor necrosis factor receptor 1 (TNFR1) is a receptor for tumor necrosis factor alpha (TNF-?), a mulitifunctional proinflammatory cytokine. Produced in activated monocytes, TNF-? has effects on lipid metabolism, coagulation, insulin resistance, and endothelial function (1). TNFR1 is activated by binding to TNF- ? or homotrimeric lymphotoxin-?, which leads to recruitment of caspase 8 to the activated receptor by FADD. This formation of death inducing signaling complex (DISC) lead to caspase 8 proteolytic activation and cascade of caspases mediating apoptosis (2).
Related Pathway
Apoptosis
Cytokine-cytokine receptor interaction
MAPK signaling pathway

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WB Image
Western blot - TNF Receptor I antibody [EP1651AY]; Anti-TNF Receptor I antibody [EP1651AY] at 1/500 dilution + human brain tissue lysate at 10 µg.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 51 kDa.Observed band size : 51 kDa.

 

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