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Home Antibody All anti-TMEM38A antibodies

Anti-TMEM38A Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306888
  • Rabbit Polyclonal TMEM38A Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC411389) , 20ug Explanation
100ug 325 In Stock
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WB(1)
IF(1)
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Also for TMEM38A (NM_024074)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenTMEM38A antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human TMEM38A.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens transmembrane protein 38A (TMEM38A)
Alternative NameTRIC-A; TRICA
Database LinkNP_076979
Entrez Gene 79041 Human
Entrez Gene 74166 Mouse
Entrez Gene 306327 Rat
FunctionTMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
Related PathwayTransmembrane

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of TMEM38A in rat skeletal muscle tissue lysate with TMEM38A antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
IF Image
Immunofluorescence of TMEM38A in mouse skeletal muscle tissue with TMEM38A antibody at 20 ug/mL.

 

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