Home Antibody All anti-TMEM38A antibodies
Also for TMEM38A (NM_024074)
|TMEM38A antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human TMEM38A.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens transmembrane protein 38A (TMEM38A)|
Entrez Gene 79041 Human
Entrez Gene 74166 Mouse
Entrez Gene 306327 Rat
|TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.|
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Western blot analysis of TMEM38A in rat skeletal muscle tissue lysate with TMEM38A antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
Immunofluorescence of TMEM38A in mouse skeletal muscle tissue with TMEM38A antibody at 20 ug/mL.