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Home Antibody All anti-TCIRG1 antibodies

Anti-TCIRG1 Antibody Polyclonal

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA319811 Rabbit Polyclonal TCIRG1 Antibody 100ug $325 3-7 Days
LC416888 TCIRG1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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WB(1)

OriGene Data

ImmunogenTCIRG1 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human TCIRG1.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsELISA, WB: 0.5 ug/ml
Predicted MW Explanation 91 kDa
BufferTCIRG1 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification TCIRG1 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (TCIRG1), transcript variant 1
Alternative Namea3; Atp6i; ATP6N1C; ATP6V0A3; OC-116kDa; OC116; OPTB1; Stv1; TIRC7; Vph1
Database LinkNP_006010
Entrez Gene 10312 Human
Entrez Gene 27060 Mouse
Entrez Gene 293650 Rat
FunctionTCIRG1 Antibody: The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.
Related PathwayTransmembrane Oxidative phosphorylationMetabolic pathwaysLysosomeVibrio cholerae infectionEpithelial cell signaling in Helicobacter pylori infection

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of TCIRG1 in EL4 cell lysate with TCIRG1 antibody at 0.5 ug/ml in (A) the absence and (B) the presence of blocking peptide.
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