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Anti-TCIRG1 Antibody Polyclonal
Also for TCIRG1 (NM_006019)
|TCIRG1 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human TCIRG1.|
|Human, Mouse, Rat
||ELISA, WB: 0.5 ug/ml
|TCIRG1 Antibody is supplied in PBS containing 0.02% sodium azide.|
|TCIRG1 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (TCIRG1), transcript variant 1|
|a3; Atp6i; ATP6N1C; ATP6V0A3; OC-116kDa; OC116; OPTB1; Stv1; TIRC7; Vph1|
|TCIRG1 Antibody: The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.|
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Western blot analysis of TCIRG1 in EL4 cell lysate with TCIRG1 antibody at 0.5 ug/ml in (A) the absence and (B) the presence of blocking peptide.