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Home Antibody All anti-TBK1 antibodies

Anti-TBK1 Antibody

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SKU Description Amount Price Availability*  
TA320202 Goat Polyclonal TBK1 (aa514-527) Antibody 100ug $325 3-7 Days
LC415713 TBK1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)

OriGene Data

ImmunogenPeptide with sequence C-TIETSLQDIDSRLS, from the C or N Terminus of the protein sequence according to NP_037386.1
Clone Name IsotypeIgG
Species ReactivityTest: Human. Expected from seq similarity: Human Concentration0.5mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1-3ug/ml, ELISA: 1:128,000
Predicted MW Explanation 83.6kDa
BufferSupplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
Note Approx 85kDa band observed in lysates of cell line HeLa (calculated MW of 83.6kDa according to NP_037386.1). Recommended concentration: 1-3µg/ml. An additional band of unknown identity was also consistently observed at 24kDa. This band was successfully blocked by incubation with the immunizing peptide.

Reference Data

Target NameHomo sapiens TANK-binding kinase 1 (TBK1)
Alternative NameNAK; T2K
Database LinkNP_037386
Entrez Gene 29110 Human
FunctionThe NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010].
Related PathwayProtein KinaseDruggable Genome Toll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayCytosolic DNA-sensing pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

Anti-TBK1 (1ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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