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Home Antibody All anti-TANK antibodies

Anti-TANK Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306341 Rabbit Polyclonal TANK Antibody 100ug $325 In Stock
LC418162 TANK HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenTANK antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human TANK.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot Dependent
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens TRAF family member-associated NFKB activator (TANK), transcript variant 1
Alternative NameI-TRAF; ITRAF; TRAF2
Database LinkNP_004171
Entrez Gene 10010 Human
Entrez Gene 21353 Mouse
Entrez Gene 252961 Rat
FunctionTANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappaB. This activation of NF-kappaB occurs through an association with the kinases IKKepsilon and TBK1. More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the IkappaB complex. This suggests that in addition to the possibility that TBK1 and IKKepsilon activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-kappaB proteins. At least two isoforms of TANK are known to exist.
Related PathwayDruggable Genome RIG-I-like receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of TANK in Daudi cell lysate with TANK antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
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Immunohistochemistry of TANK in rat spleen tissue with TANK antibody at 10 ug/ml.
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