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Home Antibody All anti-TP53 antibodies

Anti-TP53 TRUEMAB Antibody clone DO-1

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA804804 TP53 mouse monoclonal antibody, clone DO-1 100ul $325 In Stock
LC400186 TP53 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF804804 Carrier-free (BSA/glycerol-free) TP53 mouse monoclonal antibody, clone OTIDO-1 (formerly DO-1) 100ug $450 3-4 Weeks
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WB(1)
IHC(1)

OriGene Data

ImmunogenRecombinant human wild type p53 protein expressed in E. coli.
Clone Nameclone DO-1 IsotypeIgG2a
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IHC Suggested Dilutions WB 1:2000, IHC 1:150,
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from cell culture supernatant by affinity chromatography

Reference Data

Target NameHomo sapiens tumor protein p53 (TP53), transcript variant 1
Alternative NameBCC7; LFS1; P53; TRP53
Database LinkNP_000537
Entrez Gene 7157 Human
FunctionThis gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013].
Related PathwayStem cell - PluripotencyTranscription FactorsDruggable Genome MAPK signaling pathwayCell cyclep53 signaling pathwayApoptosisWnt signaling pathwayNeurotrophin signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TP53 (RC200003, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TP53.
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-TP53 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA804804)
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