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Anti-DCC TRUEMAB Antibody Clone OTI4A1
TrueMAB Antibodies - Made against Authentic Protein Antigens
|Full length human recombinant protein of human DCC (NP_005206) produced in HEK293T cell.|
|| WB 1:200,
|PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography
|Homo sapiens DCC netrin 1 receptor (DCC)|
|CRC18; CRCR1; IGDCC1; MRMV1; NTN1R1|
Entrez Gene 1630 Human
|This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]. |
|TransmembraneDruggable Genome Axon guidancePathways in cancerColorectal cancer|
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DCC (RC218506, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DCC.