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Home Antibody All anti-FEN1 antibodies

Anti-FEN1 CONJUGATED Antibody Clone OTI2B2

TrueMAB™ Antibodies - Made against Authentic Protein Antigens


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA802774AM FEN1 mouse monoclonal antibody,clone 2B2, Biotinylated 100ul $600 1-2 Weeks
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OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 117-380 of human FEN1 (NP_004102) produced in E.coli.
Clone NameClone OTI2B2 IsotypeIgG1
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application * Suggested Dilutions
Predicted MW Explanation 42.4 kDa
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens flap structure-specific endonuclease 1 (FEN1)
Alternative NameFEN-1; MF1; RAD2
Database LinkNP_004102
FunctionThe protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008].
Related PathwayStem cell - PluripotencyDruggable Genome DNA replicationBase excision repairNon-homologous end-joining

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