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Anti-DOCK2 TRUEMAB Antibody Clone OTI7G2

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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SKU Description Amount Price Availability*  
TA802698 DOCK2 mouse monoclonal antibody, clone OTI7G2 (formerly 7G2) 100ul $325 In Stock
CF802698 Carrier-free (BSA/glycerol-free) DOCK2 mouse monoclonal antibody, clone OTI7G2 (formerly 7G2) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(1)
IHC(7)

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 1544-1830 of human DOCK2 (NP_004937) produced in E.coli.
Clone NameClone OTI7G2 IsotypeIgG2a
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IHC Suggested Dilutions WB 1:2000, IHC 1:150,
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens dedicator of cytokinesis 2 (DOCK2)
Alternative NameFLJ46592; KIAA0209
Database LinkNP_004937
Entrez Gene 1794 Human
FunctionThe protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011].
Related PathwayDruggable Genome Chemokine signaling pathwayFc gamma R-mediated phagocytosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOCK2 (RC211198, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DOCK2.
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-DOCK2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802698)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-DOCK2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802698)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-DOCK2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802698)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-DOCK2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802698)
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Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-DOCK2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802698)
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Immunohistochemical staining of paraffin-embedded Human bladder tissue within the normal limits using anti-DOCK2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802698)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-DOCK2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802698)
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