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Home Antibody All anti-TYMS antibodies

Anti-TYMS TRUEMAB Antibody Clone OTI1B1

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA801664 TYMS mouse monoclonal antibody, clone OTI1B1 (formerly 1B1) 100ul $325 In Stock
LC420700 TYMS HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF801664 Carrier-free (BSA/glycerol-free) TYMS mouse monoclonal antibody, clone OTI1B1 (formerly 1B1) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(1)
IHC(4)

OriGene Data

ImmunogenFull length human recombinant protein of human TYMS (NP_001062) produced in E.coli.
Clone NameClone OTI1B1 IsotypeIgG1
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IHC Suggested Dilutions WB 1:2000, IHC 1:150,
Predicted MW Explanation 35.5 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens thymidylate synthetase (TYMS)
Alternative NameHST422; TMS; TS
Database LinkNP_001062
Entrez Gene 7298 Human
FunctionThymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008].
Related PathwayDruggable Genome Pyrimidine metabolismOne carbon pool by folateMetabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TYMS (RC204814, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TYMS.
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-TYMS mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801664)
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-TYMS mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801664)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-TYMS mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801664)
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Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-TYMS mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801664)
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