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Anti-ALK TRUEMAB Antibody Clone OTI3E7
TrueMAB Antibodies - Made against Authentic Protein Antigens
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|Full length human recombinant protein of human ALK (NP_004295) produced in HEK293T cell.|
|PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from cell culture supernatant by affinity chromatography
|Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK)|
Entrez Gene 238 Human
|This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011].|
|Protein KinaseDruggable Genome |
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ALK (RC222485, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ALK.
ALK Luminex with 15B2 Capture (TA801288) and 3E7 Detection (TA801144) Antibodies. Substrate used: full length HEK293 cells expressed recombinant ALK protein (TP322485).
ALK Luminex with 14E4 Capture (TA801412) and 3E7 Detection (TA801144) Antibodies. Substrate used: full length HEK293 cells expressed recombinant ALK protein (TP322485).