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Anti-FGFR3 TRUEMAB Antibody Clone OTI1B10

TrueMAB™ Antibodies - Made against Authentic Protein Antigens


Specifications Citations (1) Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA801078 FGFR3 mouse monoclonal antibody, clone OTI1B10 (formerly 1B10) 100ul 379
In Stock
LC424902 FGFR3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF801078 Carrier-free (BSA/glycerol-free) FGFR3 mouse monoclonal antibody, clone OTI1B10 (formerly 1B10) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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Also for FGFR3 (NM_000142)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 23-375 of human FGFR3 (NP_000133) produced in SF9 cell.
Clone NameClone OTI1B10 IsotypeIgG1
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IHC, IF Suggested Dilutions WB 1:2000, IHC 1:150,
Predicted MW Explanation 85.7 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens fibroblast growth factor receptor 3 (FGFR3), transcript variant 1
Alternative NameACH; CD333; CEK2; HSFGFR3EX; JTK4
Database LinkNP_000133
Entrez Gene 2261 Human
FunctionThis gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009].
Related PathwayProtein KinaseTransmembraneDruggable Genome MAPK signaling pathwayEndocytosisRegulation of actin cytoskeletonPathways in cancerBladder cancer

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* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FGFR3 (RC215533, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FGFR3.
Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-FGFR3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801078)
Figure from citation: Immunohistochemical and Immunofluorescense staining with anti-BGN and anti-FGFR3 of serial sections of adult human testis tissue with full spermatogenesis and fetal bone sample (gestational week 10). Scale bar is 50 um for all images. Dilution: 1:200 View Citation


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