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Anti-PTEN TRUEMAB Antibody Clone OTI1C3

TrueMAB™ Antibodies - Made against Authentic Protein Antigens


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA801053 PTEN mouse monoclonal antibody, clone OTI1C3 (formerly 1C3) 100ul 379
In Stock
LC424803 PTEN HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF801053 Carrier-free (BSA/glycerol-free) PTEN mouse monoclonal antibody, clone OTI1C3 (formerly 1C3) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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OriGene Data

ImmunogenFull length human recombinant protein of human PTEN (NP_000305) produced in SF9 Cell.
Clone NameClone OTI1C3 IsotypeIgG1
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB Suggested Dilutions WB 1:2000, IHC 1:100,
Predicted MW Explanation 47 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens phosphatase and tensin homolog (PTEN), transcript variant 1
Alternative Name10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
Database LinkNP_000305
Entrez Gene 5728 Human
FunctionThis gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008].
Related PathwayPhosphataseDruggable Genome Inositol phosphate metabolismPhosphatidylinositol signaling systemp53 signaling pathwayFocal adhesionTight junctionPathways in cancerMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTEN (RC202627, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTEN.


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