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Home Antibody All anti-HSD17B8 antibodies

Anti-HSD17B8 TRUEMAB Antibody Clone OTI2E12

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA800478 HSD17B8 mouse monoclonal antibody, clone OTI2E12 (formerly 2E12) 100ul $325 In Stock
LC415425 HSD17B8 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF800478 Carrier-free (BSA/glycerol-free) HSD17B8 mouse monoclonal antibody, clone OTI2E12 (formerly 2E12) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(2)
IHC(1)
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Also for HSD17B8 (NM_014234)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 57-261 of human HSD17B8 (NP_055049) produced in E.coli.
Clone NameClone OTI2E12 IsotypeIgG1
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IHC Suggested Dilutions WB 1:2000, IHC 1:150,
Predicted MW Explanation 26.8 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens hydroxysteroid (17-beta) dehydrogenase 8 (HSD17B8)
Alternative NameD6S2245E; dJ1033B10.9; FABG; FABGL; H2-KE6; HKE6; KE6; RING2; SDR30C1
Database LinkNP_055049
Entrez Gene 7923 Human
FunctionIn mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008].
Related PathwayDruggable Genome Androgen and estrogen metabolismMetabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HSD17B8 (RC203806, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HSD17B8.
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Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-HSD17B8 monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-HSD17B8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA800478)
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