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Home Antibody All anti-IDH1 antibodies

Anti-IDH1 CONJUGATED Antibody Clone OTI3G9

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA800406FM IDH1 mouse monoclonal antibody,clone 3G9, DyLight 594 conjugated 100ul $600 1-2 Weeks

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OriGene Data

ImmunogenSynthetic peptide around the R132H mutation region of the human IDH conjugated to KLH
Clone NameClone OTI3G9 IsotypeIgG1
Species ReactivityHuman , Dog , Rat , Mouse Concentration1 mg/ml
Guaranteed Application * Suggested Dilutions
Predicted MW Explanation 46.5 kDa
Buffer
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens isocitrate dehydrogenase 1 (NADP+), soluble (IDH1), transcript variant 1
Alternative NameHEL-216; HEL-S-26; IDCD; IDH; IDP; IDPC; PICD
Database LinkNP_005887
FunctionIsocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq, Jul 2008].
Related Pathway Citrate cycle (TCA cycle)Glutathione metabolismMetabolic pathways

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