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Home Antibody All anti-F13A1 antibodies

Anti-F13A1 CONJUGATED Antibody Clone 1C9

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA800337GM
  • F13A1 mouse monoclonal antibody,clone 1C9, DyLight 633 conjugated
100ul 600 1-2 Weeks
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Also for F13A1 (NM_000129)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human F13A1 (NP_000120) produced in HEK293T cell.
Clone NameClone 1C9 IsotypeIgG1
Species ReactivityHuman Concentration0.5mg/ml
Guaranteed Application * Suggested Dilutions
Buffer
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens coagulation factor XIII, A1 polypeptide (F13A1)
Alternative NameF13A
Database LinkNP_000120
FunctionThis gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008].
Related Pathway
Hemostasis

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