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Anti-SIPA1 GAT Antibody Polyclonal
UltraMAB Antibodies - Validated with 10K Protein Chip
Also for SIPA1 (NM_153253)
|DNA immunization. This antibody is specific for the C Terminus Region of the target protein.|
|ELISA, IHC, IF
||ELISA: 1:100-1:2000; IHC: 1:600; IF: 1:150
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody. (Protein A or G Sepharose)
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens signal-induced proliferation-associated 1 (SIPA1), transcript variant 1|
|The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq]|
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Immunohistochemical staining of human rectum shows strong nuclear and cytoplasmic positivity in glandular cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.
Immunofluorescent staining of human cell line U-251 MG shows positivity in nucleoli & nucleus but not nucleoli.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.