Home Antibody All anti-TMEM173 antibodies
Anti-TMEM173 GAT Antibody Polyclonal
Generated by Genomic Immunization
Also for TMEM173 (NM_198282)
|DNA immunization. This antibody is specific for the C Terminus Region of the target protein.|
|| WB 1:20000, ELISA 1:100-1:2000
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens transmembrane protein 173 (TMEM173), transcript variant 1|
|ERIS; hMITA; hSTING; MITA; MPYS; NET23; SAVI; STING|
Entrez Gene 340061 Human
|TMEM173 acts as a facilitator of innate immune signaling. TMEM173 is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.|
| RIG-I-like receptor signaling pathwayCytosolic DNA-sensing pathway|
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TMEM173 (RC208418, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TMEM173.