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Anti-MYB GAT Antibody Polyclonal
UltraMAB Antibodies - Validated with 10K Protein Chip
|DNA immunization. This antibody is specific for the Middle Region of the target protein.|
||WB: 1:5000-1:20000; ELISA: 1:100-1:2000; IHC: 1:10-1:2000; IHC-P 1:10-1:2000
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody. (Protein A or G Sepharose)
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens v-myb avian myeloblastosis viral oncogene homolog (MYB), transcript variant 2|
|c-myb; c-myb_CDS; Cmyb; efg|
|The c-Myb proto-oncogene is a 75 kDa protein involved in growth regulation and differentiation in many different cell types but it is predominantly expressed in immature hemopoietic cells where it plays an important role in cell proliferation. c-Myb activity is directly regulated by cyclin D1 and CDKs and it is believed that c-Myb activity is regulated during the cell cycle in hematopoietic cells (2). Disrupting c-myb function might, therefore, prove an effective therapeutic strategy for controlling leukemic cell growth (3). c-Myb binds to promoter sequences of genes such as c-Myc or Bcl-2 that are expressed in cutaneous T-cell lymphoma.|
Wnt Signaling Pathway
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Western Blot: c-Myb Antibody - Western Blot was performed using affinity purified SEQer MYB antibody. The lanes contain 5-30ug of a whole cell extract. Final concentration of antibodies = 0.1ug/ml (1:10,000 dilution).
Western Blot: c-Myb Antibody - Samples: Lane 1: Marker: 250, 130, 95, 72, 55, 36, 28, 17, 11 / Lane 2: RT-4 / Lane 3: U-251MG sp / Lane 4: Human Plasma / Lane 5: Liver / Lane 6: Tonsil; Target weight: 85, 82, 76, 72, 41, 31 (splice variants)