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Anti-IL10RA TRUEMAB Antibody Clone 1C7
TrueMAB Antibodies - Made against Authentic Protein Antigens
Also for IL10RA (NM_001558)
|Full length human recombinant protein of human IL10RA(NP_001549) produced in HEK293T cell.|
|| WB 1:4000,
|PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography (Protein A or G Sepharose)
|Homo sapiens interleukin 10 receptor, alpha (IL10RA), transcript variant 1|
|CD210; CD210a; CDW210A; HIL-10R; IL-10R1; IL10R|
|The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]. |
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL10RA (RC207020, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IL10RA.